Impaired hepatic removal of galectin–3 and association with worse liver function in patients with alcoholic liver cirrhosis
C Buechler, R Wiest, S Bauer, J Wanninger, M Neumeier, S Farkas, M Scherer, A Schaeffler · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Objective: Galectin–3 eliminates advanced glycation end products (AGE) and thereby protects from their cytotoxic effects. Recently, we demonstrated higher galectin-3 in portal venous serum (PVS) compared to hepatic venous serum (HVS) in patients with normal liver function, suggesting that the liver removes galectin–3. Galectin–3 is induced in cirrhotic liver but so far it has not been analysed whether hepatic galectin–3 synthesis is associated with an elevated hepatic release of galectin–3 and/or worse liver function in humans. Methods: Serum galectin-3 was measured by ELISA in PVS, HVS and SVS of 33 patients wi…
