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Fibrogenic genotype-phenotype correlations in selected BXD recombinant inbred mouse lines: Closer to life?!
N Fund, R Hall, S Dooley, F Lammert, R Müllenbach · Zeitschrift für Gastroenterologie · 2011 · Heft 01
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1139429
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2011
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Zusammenfassung
BxD mice are inbred F2 lines derived from a cross of laboratory strains C57BL/6J and DBA/2J. Array analyses in untreated livers reveal a normal distribution of gene expression among the >30 lines, reflecting the expected distribution in populations resulting from complex gene regulation (Figure 1). We hypothesised that "extreme expressors" (high or low) of fibrosis-relevant genes represent a better reflection of real-life gene expression variation than knockout animals. Thus they may offer more realistic models to study the consequences of long-term dysregulated expression of fibrogenic or cancerogenic genes. To…
Schlagworte
TGF-beta
fibrogenesis
gene expression
proliferation
wound healing
Apoptosis
Zeitschrift für Gastroenterologie
