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Lipocalin-2 gene expression and production in a model of acute phase response reaction

M Pascucci, A Bianchi, P Ramadori, S Sultan, G Martius · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1139431
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Pascucci, A Bianchi, P Ramadori, S Sultan, G Martius
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269488

Zusammenfassung

Lipocalin-2 (LCN-2) is a 25k-Da secretory protein expressed by various tissues, currently used as renal injury marker and recently hypothesized as involved in obesity-related pathologies, as type 2 diabetes mellitus and metabolic syndrome. In the current study a rat model of turpentine oil (TO) induced acute phase reaction (APR) was used to study the pattern of gene expression of LCN-2 in liver and kidney. Serum LCN-2 concentration measured by ELISA test showed a significant increase which reached ≈ 200µg/ml at 48 hours after injection. RT-PCR analysis showed up-regulation of LCN-2 mRNA expression in rat liver s…

Schlagworte

Acute Phase Reaction Lipocalin-2 After Acute-Phase Proteins Acute-Phase Reaction C-Reactive Protein Diabetes Mellitus Obesity Zeitschrift für Gastroenterologie