CareLit Fachartikel
Vitamin D ameliorates stress ligand expression elicited by free fatty acids in hepatic stellate cells
S Seydel, A Beilfuss, A Kahraman, K Aksoy, G Gerken, H Akkiz, A Canbay · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1139432
CareLit-ID
Jahr
2011
Publikation
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Zusammenfassung
Background/Aims: Hepatic stellate cells (HSC) play an important role as the major source of fibrillar and nonfibrillar matrix proteins in the process of liver fibrosis. Natural killer (NK) cells have an antifibrotic effect through killing activated HSC. Major histocompatibilitiy complex class I (MHC-I)- related molecules, MICA and MICB, function as ligands for the NKG2D receptor and play a role in HSC susceptibility to NK cells during hepatic inflammation. The aim of this study was to investigate the effect of vitamin D2 and free fatty acids (FFA) on stress ligands and profibrotic activity in LX-2 cells and huma…
Schlagworte
MICA/B
NKG2D ligands
hepatic stellate cells
vitamin D
After
Zeitschrift für Gastroenterologie
