Jagged-1 signalling is required in liver fibrogensis
H Weng, Y Liu, I Ilkavets, H Shen, V Zimmer, F Lammert, A Mueller, F Herweck, C Stump, PR Mertens, S Dooley · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aims: Mutation of Jagged-1 gene, a Notch ligand, leads to Alagille syndrome. However, patients with Alagille syndrome usually do not progress into serious liver fibrosis. In the present study, we investigated the role of Jagged-1 in liver fibrogenesis. Methods: Jagged-1 expression in diseased human and mouse livers were evaluated by immunohistochemistry and Western blot. The effect of a Jagged-1 was examined in hepatic stellate cells (HSCs). Results: Immunohistochemistry and Western blot analysis revealed that protein expression of Jagged-1 in liver tissues from 2-week bile duct ligated mice was sig…
