De novo lipogenesis is required for insulin-mediated hepatocarcinogenesis and contributes to human liver cancer prognosis
DF Calvisi, K Evert, V De Murtas, G Gasparetti, G Destefanis, S Mattu, F Dombrowski, M Evert · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
To study the oncogenic effect of chronic and elevated secretion of insulin on hepatocytes in the presence of mild hyperglycemia, we developed a model of pancreatic islet transplantation into the liver via the portal vein. In this model, islets of a donor rat are transplanted into the liver of a recipient diabetic rat, with resulting local hyperinsulinism that leads to the development of preneoplastic lesions and hepatocellular carcinoma (HCC). Here, we analyzed the activation of the lipogenic pathway in rat preneoplastic lesions and HCC. The results were compared with those obtained in a collection of human HCC…
