Hepatic Steatosis as a Result of Altered Lipid Metabolism in Mice with Adipocyte-specific Fatp4-deficiency under High-fat Diet
LS Lenz, J Marx, W Chamulitrat, I Kaiser, HJ Gröne, G Liebish, W Stremmel, T Herrmann · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Fatp4 (fatty acid transport protein 4) is expressed in adipose tissue and exhibits acyl-CoA synthetase activity for long chain fatty acids (LCFA). Its role in cellular fatty acid uptake, metabolism as well as its localization are still controversial. Aims: To characterize Fatp4 functions in adipocytes in vivo, we generated a mouse line with adipocyte-specific inactivation of the Fatp4 gene (aP2-cre). Methods: As under standard conditions mutant mice showed no phenotypical aberrance, they were then exposed to a high-fat diet enriched in LCFA. Adipose and liver tissues were assessed histologically. U…
