CareLit Fachartikel
Delta like ligand 4 expression in the endothelium of hepatocellular carcinoma is associated with poor tumor differentiation and early tumor stages
C Mogler, H Weng, S Singer, P Schirmacher, T Longerich · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1139440
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Most tumors are stroma-poor but highly vascularised. Overexpression of the tip cell marker and Notch ligand delta like ligand 4 (DLL4) has been described in many tumor entities but not yet investigated in human HCCs. First attempts have been made to further characterize tumor vasculature, but to date no clear data exist about sprouting angiogenesis and its relation to malignant transformation in HCCs (“angiogenic switch“). Methods: Tissue micorarrays (TMAs) including overall 192 HCCs, 9 Dysplastic nodules (DN) and 12 normal liver s…
Schlagworte
DLL4
HCC
angiogenesis
Tumor
Association
Breast
Zeitschrift für Gastroenterologie
