Serum Interferon-gamma-inducible protein 10 (CXCL10) is a predictive marker of fibrosis progression after liver transplantation for hepatitis C infection
ML Berres, C Trautwein, M Schmeding, D Eurich, F Tacke, M Bahra, P Neuhaus, UP Neumann, HE Wasmuth · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Recurrence of liver fibrosis after liver transplantation (LT) for hepatitis C infection (HCV) is responsible for graft loss and patient mortality. Although the contribution of the immune system to fibrosis recurrence is anticipated, systematic studies evaluating immune parameters as predictive markers of allograft fibrosis are lacking. The infiltration of immune cells into the graft is governed by different chemokines including CCL2 and the CXCR3 ligands CXCL9, CXCL10 and CXCL11. We here assessed the predictive value of serum levels of these chemokines with regards to fibrosis recurrence after LT for hepat…
