CareLit Fachartikel

HBsAg-specific regulatory T cells are present in patients with chronic HBV infection

T Bauer, JJ Wenzel, B Huber, W Jilg · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1139448
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
T Bauer, JJ Wenzel, B Huber, W Jilg
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269658

Zusammenfassung

We analysed the frequency and phenotypic characteristics of HBsAg-specific regulatory T cells (HBsAg-Treg) in individuals with different HBV infection status and investigated their effect on cellular immune responses as well as the mechanisms underlying their regulatory function. In addition we assessed, whether HBsAg-Treg have an inhibitory effect on anti-HBs production by suppressing corresponding T helper cell functions. A total of 45 subjects including patients with chronic (n=16) and resolved (n=10) hepatitis B, solely anti-HBc-positive (n=9) and vaccinated (n=10) individuals were tested. Immune responses w…

Schlagworte

HBV Hepatitis B chronic HBV infection regulatory T cells Hepatitis Zeitschrift für Gastroenterologie