CareLit Fachartikel
IL28B genotype and hepatitis C virus specific T cell response
D Grimm, C Neumann-Haefelin, N Kersting, HE Blum, R Thimme · Zeitschrift für Gastroenterologie · 2011 · Heft 01
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1139450
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Jahr
2011
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Zusammenfassung
Single nucleotide polymorphisms (SNP) in the IL28B gene region on chromosome 19 are important in predicting natural course and therapy outcome in chronic hepatitis C virus (HCV) infection. This finding might be of major importance in clinical treatment decision-making in the near future. Until now, the mechanisms behind this observation are unknown. We could show previously that CD8+ T cells play a pivotal role in HCV pathogenesis and viral clearance. Therefore, we asked whether the IL28B genotype is mechanistically linked to HCV-specific CD8+ T cell responses. We analyzed CD8+ T cell responses in a well-charact…
Schlagworte
CD8+ T cell
HCV
IL28B
SNP
immunology
Hepatitis
Observation
Blood
Zeitschrift für Gastroenterologie
