Therapy response in chronic hepatitis C patients is influenced by 25-OH Vitamin D serum levels and VDR (NR1I1) gene polymorphisms
K Baur, JC Mertens, J Schmitt, R Iwata, B Stieger, P Frei, B Seifert, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Chronic hepatitis C virus (HCV) infection is a major cause of end stage liver disease. Non-parenchymal liver cells involved in inflammation and fibrogenesis express functional vitamin D receptor (VDR). Vitamin D is a known immunomodulator. We investigated effects of vitamin D serum levels and common polymorphisms (SNP) in the VDR (NR1I1) gene on hepatic inflammation & therapy response in chronic HCV-patients. Methods: 156 patients were included for VDR genotyping (Cdx2 rs11568820, bat genptype: Bsm rs1544410, Apa rs 7975232 and Taq rs 731236). Serum vitamin D levels were measured in patients with early fib…
