Contribution of progenitor cells in experimental right heart hypertrophy induced by pulmonary artery ligation
H Luitel, A Sydykov, B Kojonazarov, BK Dahal, D Kosanovic, W Seeger, F Grimminger, HA Ghofrani, RT Schermuly · Pneumologie · 2011 · Heft 03
Bibliografische Angaben
Zusammenfassung
Background: Right ventricular hypertrophy (RVH) is an adaptive response to increased hemodynamic load. Previous studies on pulmonary hypertension and RV remodeling processes have reported different mechanisms in right ventricular remodeling, however, the contribution of progenitor cells and their homing mechanism is still unclear. Methods: RV hypertrophy was induced in male C57Bl/6 mice by pulmonary artery banding (PAB). The functional changes of RV were assessed by ultrasound biomicroscopy (UBM) and correlated with invasive measurements. Further we assessed RV fibrosis, cardiac myocyte size and expression of hy…
