Positive association of a Cry1 polymorphism with EDS
A. Schirmacher, A. Heidbreder, S. Happe, R. Kelsch, T. Meißner, G. Mayer, P. Young · Klinische Neurophysiologie · 2011 · Heft 03
Bibliografische Angaben
Zusammenfassung
Introduction: Excessive daytime sleepiness (EDS) is the most common symptom related to organic, psychiatric and to other sleep disorders. It presents as the dissociation from the circadian rhythm and is the leading symptom of sleep disorders, which are summarized as hypersomnias of central origin. Our question was to what extent EDS, which could be interpreted as a symptom of a disturbed circadian rhythm may be linked to members of the clock genes. Therefore we performed an association study of Cry1. Methods: We performed an association study in 86 German Caucasian patients (33 female, 53 male, mean age 39.3±13.…