Prominent 3–12Hz activity in the subthalamic nucleus of a patient with generalized dystonia

Introduction: There is growing evidence that synchronised activity across populations of neurons might underlie impairment in some diseases. Several studies have shown pathologically enhanced synchronous oscillatory activity within and between the basal ganglia and cerebral cortex in patients with Parkinson's disease that is prominent in the β frequency band (13–30Hz). Conversely, dystonia patients show enhanced synchrony at low frequency (4–12Hz) recorded from the globus pallidus internus suggesting disease specific distinct temporal patterns of synchronized neuronal activity recorded from the basal ganglia in…