Morphological and neurocognitive sequelae following chemotherapy for leukemia in early childhood
M Genschaft, T Hübner, F Plessow, F Krone, VN Ikonomidou, A Abolmaali, B Gruhn, P Hernaiz, A Hofmann, E Holfeld, P Kramm, P Vorwerk, T Hummel, C Ikonomidou, C Kirschbaum, MN Smolka, M Suttorp · Klinische Pädiatrie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: We studied long-term consequences of chemotherapy for ALL on the morphology of brain structures, cognitive functions and smell to explore the hypothesis that chemotherapy, when administered during vulnerable period of brain development, may cause neuronal damage. Methods: We examined 19 ALL survivors and 19 age- and sex-matched controls, ages 15–22yrs. All patient developed ALL prior to age 10yrs and did not exhibit CNS involvement. They were treated according to the BFM and COALL protocols. Patients with relapse or irradiation were excluded from the study. Based on T1 weighted magnetic resonance i…
