Septin 9 methylation in colorectal cancer screening using peripheral blood and tissue samples
K Tóth, O Galamb, S Spisák, F Sipos, B Wichmann, K Leiszter, G Valcz, A Kalmár, VÁ Patai, A Schöller, R Wasserkort, Z Tulassay, B Molnár · Zeitschrift für Gastroenterologie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Colorectal cancer (CRC) is one of the frequent cause of cancer-related death worldwide. Present screening tests do not have respective specificity and sensitivity; furthermore the compliance is very low. Detection of DNA methylation is possible from tissue and peripheral blood as well. Every cell type has unique DNA methylation fingerprint. Differences between carcinoma and healthy samples can be detected with the identification of methylated sequence. Aim: Our aims were to give an overview about septin 9 methylation marker verification and confirmation from peripheral blood and biopsy samples, furth…
