DNA methylation contributes to the colonic adenoma-dysplasia-carcinoma development in a non-sequential line
ÁV Patai, O Galamb, A Kalmár, B Wichmann, G Valcz, Á Patai, K Leiszter, K Tóth, S Spisák, F Sipos, A Schöller, T Krenács, P Miheller, Z Tulassay, B Molnár · Zeitschrift für Gastroenterologie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: The adenoma-dysplasia-carcinoma sequence (ADCS) driven by genetic mutations is a widely accepted concept in colorectal carcinogenesis. In some proximal cancer arising from different precursor lesions DNA methylation has been shown to be an important mechanism and a distinct phenotype of colorectal cancer (CRC), CpG island methylator phenotype (CIMP) was described. In distal CRC DNA methylation has scarcely been studied. Aims: To study the role of DNA methylation during ADCS in the left side of the colon and find a set of DNA methylation markers that distinguishes between the different stages. Our fur…
