Immunoexpression of PAX 8 in endometrial cancer: Relation to high grade carcinoma and p53

PAX 8 is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and the Müllerian system and plays an essential role in cell proliferation. The purpose of this study was to evaluate the association between p53 and PAX 8 expression and the clinical value of PAX 8 in endometrial carcinoma. We detected 106 consecutive patients with primary endometrial carcinoma (type I/endometrioid, n=84; type II/non-endometrioid, n=20; rare subtypes, n=2) who were treated at our institution between 1999 and 2009. Out of the 106 patients 97 cases were eligible for further investigations. PAX 8 and p53 expres…