COMP-Angiopoietin-1 suppresses the neuropathic alterations in sciatic nerve of leptin-deficient ob/ob mice
J Kosacka, M Nowicki, N Klöting, M Kern, M Stumvoll, I Bechmann, H Serke, M Blüher · Diabetologie und Stoffwechsel · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Aims: The leptin-deficient ob/ob mice are a generally accepted animal model of type-2 diabetes dependent peripheral neuropathy. The ob/ob mice exhibit over 50% body fat, insulin resistance, hyperglycemia, alterations of peripheral nerve fibres and endoneural microvessels. Since cartilage oligomeric matrixprotein (COMP)-Ang-1, a soluble and stabile form of Ang-1 promotes angiogenesis and nerve growth, we hypothesize that it could induce the regeneration of nerve fibres and endoneural microvessels of peripheral nerve in diabetic mice. Methods: In this study, COMP-Ang-1 (100ng/ml) or NaCl (5µl/g body weigh) were in…
