Identification of Two Molecular and Clinical Distinct Entities of Posterior Fossa Ependymoma
H Witt, SC Mack, M Ryzhova, S Bender, M Sill, R Isserlin, A Benner, T Hielscher, T Milde, M Remke, DTW Jones, PA Northcott, L Garzia, KC Bertrand, A Wittmann, A von Deimling, AE Kulozik, O Witt, GD Bader, JT Rutka, P Lichter, A Korshunov, MD Taylor, SM Pfister · Klinische Pädiatrie · 2011 · Heft 11
Bibliografische Angaben
Zusammenfassung
Ependymoma is the third most common brain tumor in children, and remains incurable for as many as 45% of patients even after therapy currently consisting of maximal safe resection and radiotherapy. Despite the histological similarity of ependymomas from throughout the neuraxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. We examined two non-overlapping cohorts of 102 and 75 ependymomas by mRNA expression profiling, on two different array platforms (Affymetrix Exon 1.0 ST, Agilent 4×44K). Multiple statistical clustering methods (unsupervised consensus N…
