The placenta as a chimeric organ?
JS Fitzgerald, M Weber, S San Martin, MP San Roman, A Weise, U Markert · Zeitschrift für Geburtshilfe und Neonatologie · 2011 · Heft 11
Bibliografische Angaben
Zusammenfassung
Ziel: The mechanisms that allow a woman to immunologically tolerate pregnancy remain enigmatic. Askewed tolerance is associated with pregnancy pathologies, e.g. miscarriage and preeclampsia. Especially the behavior of first trimester trophoblasts is intriguing: they invade the decidua while evading the uterine immune system, similar to malignancies, with the goal of replacing spiral artery endothelium with endovascular trophoblast.Fetomaternal microchimerism has emerged recently as a possible means of inducing tumor cell tolerance. Also, new investigations give cause to believe that trophoblast fuse with materna…
