Pro-coagulant capacity of syncytiotrophoblastic microparticles (STBMs)
JS Fitzgerald, C Bonnke, A Brückmann, E Schleußner, M Sossdorf, W Lösche · Zeitschrift für Geburtshilfe und Neonatologie · 2011 · Heft 11
Bibliografische Angaben
Zusammenfassung
Ziel: A characteristic of the severe pregnancy pathology, preeclampsia (PE), is endothelial dysfunction as seen through vasoconstriction and platelet activation. The release of syncytiotrophoblastic microparticles (STBMs) is associated especially with severe, as opposed to mild, forms of PE. Classic STBM research has been geared to investigating their effects on the endothelial compartment, however, their thrombogenic potential is not well characterized. Aim of the study was to investigate the pro-coagulant activity of STBMs. Methodik: STBMs were derived from placenta perfusates and, after staining with FITC-lab…
