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Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

K Hochrath, A Müller, M Krawczyk, A Bücker, F Lammert · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1140461
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
K Hochrath, A Müller, M Krawczyk, A Bücker, F Lammert
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295748

Zusammenfassung

Aims: To date research involving mouse models of liver fibrosis is hampered by the need of obtaining liver specimens to quantify liver injury. Hence development of non-invasive methods is critical to monitor potential therapies for hepatic fibrosis and to reduce the number of animals included in experiments. Our aim was to establish a protocol for non-invasive quantification of liver fibrosis in mice using magnetic resonance relaxometry (MRR). Methods: We studied BALB/cJ mice (n=10) after induction of liver fibrosis with CCl4 (1.4mg/kg/week i.p. for 6 weeks) and control animals (n=11). To determine hepatic injur…

Schlagworte

MRT liver fibrosis magnetic resonance relaxometry Algorithms After Zeitschrift für Gastroenterologie