CareLit Fachartikel
Aging promotes hepatocellular steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis in mice
M Saugspier, C Dorn, C Hellerbrand · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1140464
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
Nonalcoholic steatohepatitis involves necroinflammatory activity and fibrosis, which are believed to be mediated by lipotoxicity caused by toxic metabolites from excess fatty acids. Epidemiological studies indicate that age has impact on the natural course of NAFLD. The aim of this study was to assess whether there are age dependent differences in the susceptibility to lipotoxicity and NASH in primary hepatocytes and a dietary murine model, respectively. Methods and Results: Upon stimulation with free fatty acids hepatocytes isolated from 4 week old mice revealed a significantly higher intracellular lipid accumu…
Schlagworte
NAFLD
NASH
age
lipotoxicity
Aging
Diet
After
Zeitschrift für Gastroenterologie
