Analysis of the cytokine response in a mouse model of liver ischemia / reperfusion injury
N Steinebrunner, M Al-Saeedi, H Kudsi, A Lovas, CS Falk, C Sandig, W Stremmel, P Schemmer, M Müller · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Ischemia-reperfusion injury is inevitable in liver transplantation and in liver resection. Our understanding of the molecular mechanisms underlying programmed cell death in hepatic ischemia/reperfusion (I/R) injury will provide the basis for the development of new strategies for effective inhibition of liver injury and improvement of survival of the graft.We have established a mouse model of liver ischemia and reperfusion injury. Liver ischemia is induced in anesthetized mice by cross-clamping the hepatic artery and portal vein for 45 minutes, resulting in deprivation of blood flow to approximately 70% of the li…
