Dynamic model of IL–6 and IL–1beta dependent signalling in primary murine hepatocytes
U Albrecht, A Kulawik, A Raue, J Timmer, U Klingmüller, D Häussinger, JG Bode · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
The hepatic inflammatory response is an important part of the host defence and also represents a critical regulatory event in hepatic liver regeneration. It is mainly orchestrated by a mediator based communication between the different cell types in the liver, including parenchymal cells and non-parenchymal cells, such as sessile liver macrophages (Kupffer cells). In this context, a cytokine mediated signal always depends on the background of co-acting factors and the type of target cells. In macrophages the interleukin–6 (IL–6) induced STAT3 (signal transducer and activator of transcription) activation is abrog…
