Antigen cross-presentation in the liver generates protective memory CD8+ T cells in the absence of inflammation
JP Böttcher, D Stabenow, S Debey-Pascher, A Staratschek-Jox, J Grell, B Höchst, A Limmer, I Atreya, MF Neurath, S Hegenbarth, E Schmitt, DH Busch, P van Endert, W Kolanus, C Kurts, JL Schultze, L Diehl, PA Knolle · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
The inflammatory context of antigen-presentation dictates the outcome of CD8+ T cell responses. Pathogen-induced inflammatory signals ensure the generation of an effector CD8+ T cell response and long-lasting T cell memory, whereas antigen-presentation in absence of inflammatory stimuli, e.g. of self-antigens, causes CD8+ T cell-deletion. The systemic distribution of antigens from certain pathogens without inflammatory stimuli therefore imposes the risk of deleting CD8+ T cells needed for anti-infectious defense. We hence wondered whether cross-presentation of exogenous antigens in the liver, the central organ f…
