CareLit Fachartikel
HLA-B27 has a dominant role in restricting strong CD8+ T cell responses and driving viral escape in hepatitis B virus infection
MM Kiraithe, K Nitschke, R Thimme, C Neumann-Haefelin · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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1140478
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Jahr
2012
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Zusammenfassung
Important insights into the immunobiology of HIV and HCV infection have been derived from the study of protective HLA-B27 restricted CD8+ T cell responses in these two important human viral infections. Indeed, immunodominant HLA-B27 restricted CD8+ T cell epitopes have been identified in both infections. Viral escape from these two protective epitopes is the main mechanism of T cell failure in the few HLA-B27+ patients who have a less favourable outcome. In hepatitis B virus (HBV) infection, however, the role of HLA-B27 has not been addressed so far. In addition, in contrast to HIV and HCV, viral escape is thoug…
Schlagworte
HBV
HLA-B27
T cell response
virale escape
Hepatitis
Zeitschrift für Gastroenterologie
