CareLit Fachartikel
Partial loss of immunological tolerance in CCR5-deficient mice in the murine model of concanavalin A-induced liver injury
C Wegscheid, U Panzer, G Tiegs, A Erhardt · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1140481
CareLit-ID
Jahr
2012
Publikation
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Metadaten
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Zusammenfassung
Introduction: Injection of a sublethal dose of concanavalin A (ConA) induces tolerance against the same agent within one week. Both Tregs and Th1 polarized as well as NKT cells express the chemokine receptor CCR5 and are recruited into the liver by the ligands CCL3/4/5. In this study, the role of CCR5 was investigated during ConA hepatitis and ConA tolerance induction. Methods: C57BL/6 wt and CCR5KO mice were injected with a sublethal dose of ConA or saline and restimulated with ConA after one week. Eight hours after ConA rechallenge, plasma transaminase activities and expression of cytokines and CCR5 ligands we…
Schlagworte
CCR5
Tregs
concanavalin A
Chemokine
After
Hepatitis
Cytokines
Zeitschrift für Gastroenterologie
