CareLit Fachartikel
The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells
K Becker, T Urbanik, R Boger, D Jäger, H Schulze-Bergkamen · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1140482
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Jahr
2012
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Zusammenfassung
Background and Aims: The deubiquitination enzyme CYLD has originally been identified as a gene mutated in familial cylindromatosis, an autosomal-dominant predisposition to multiple tumors of the skin appendages.[1] CYLD is an important regulator of cell proliferation, survival and invasion and is downregulated in a variety of cancers, including hepatocellular carcinoma.[2] CYLD acts as a negative regulator of NFκB-signaling and prevents the nuclear translocation of Bcl–3, a coactivator of NFκB subunits.[3] The aim of our study is to examine the effects of CYLD knockdown on the proliferation and invasion of HCC c…
Schlagworte
CYLD
hepatocellular carcinoma
After
Tumor
Cyclin D1
Zeitschrift für Gastroenterologie
