CareLit Fachartikel
TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells
S Lukowski, H Weng, X Gu, Q Li, C Gao, S Dooley, I Ilkavets · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1140485
CareLit-ID
Jahr
2012
Publikation
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Metadaten
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Zusammenfassung
Primary hepatocellular carcinoma (HCC) is a complex and heterogeneous disease of high malignancy and poor prognosis. Since the common chemotherapy regimes for HCC are insufficient, further insight into the signalling events associated with its pathophysiology may provide new targets for treatment. TGF-β, a cytokine that is prominently upregulated during chronic liver disease progression is cytostatic towards hepatocytes in early disease, whereas it is discussed to convert to a tumor promoter during progression to cancer. In an approach to identify tumorigenesis related downstream targets of TGF-β, we performed a…
Schlagworte
CCN
HCC
TGF-beta
Wisp1
Cytokine
Tumor
Zeitschrift für Gastroenterologie
