Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis
O Neumann, M Kesselmeier, B Radlwimmer, P Schemmer, J Lorenzo Bermejo, P Schirmacher, T Longerich · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer and the third leading cause of cancer mortality worldwide. Its etiologies are well-established, most prominently chronic hepatitis B (HBV) and C (HCV) virus infections and chronic alcohol abuse. About 10% of HCCs are classified as cryptogenic, but according to recent epidemiological data likely derive from nonalcoholic steatohepatitis (NASH). In contrast, the underlying molecular mechanisms are largely unknown. In order to identify host changes related to tumor etiology as well as novel driver genes of human hepatocarcinogenesis in general, we expl…
