CareLit Fachartikel
Role of basophils in immunological memory responses to pneumococcal protein antigens and S. pneumoniae infections in mice
A Bischof, C Brumshagen, R Maus, M Mack, T Welte, UA Maus · Pneumologie · 2011 · Heft 12
Dokument
1140492
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction: We have shown recently that basophils play an important role in enhancing secondary humoral memory immune responses to intact pneumococcal protein antigen, thereby markedly improving survival in a mouse model of pneumococcal sepsis. We here investigated the effect of expanded basophil pool sizes on immunization efficacies against S. pneumoniae in mice. Methods: Mice underwent primary and secondary immunization with the pneumococcal surface protein A (PspA). Basophil pool sizes were expanded immediately prior to secondary immunization by treatment with IL-3 or IL-3 complexed with anti-IL-3 antibody.…
Schlagworte
Basophils
Antigens
Blood
After
Sepsis
Pneumologie
