CareLit Fachartikel
Anti-Inflammatory and Barrier-Protective Effects of Berberine
Lena J. John, Anja Fromm, Michael Fromm, Jörg-Dieter Schulzke, Maren Amasheh · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1140635
CareLit-ID
Jahr
2012
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Zusammenfassung
Abstract The plant alkaloid berberine has been used in traditional Eastern medicine for the treatment of gastroenteritis and diarrhea. Berberine, recently established in the therapy of diabetes and hypercholesterinemia, presents defined barrier preserving effects via specific regulation of tight junction (TJ) proteins. Additionally, berberine has been shown to completely antagonize TNFα-mediated barrier defects in intestinal HT-29/B6 cell monolayers. Three signaling pathways that are involved in this regulation could be identified, namely tyrosine kinase p-src, pAkt, and NF-κB pathway. Beside its anti-inflammato…
Schlagworte
Berberine
Berberin
After
Tumor
Diabetes Mellitus
Blood Glucose
Cholesterol
Claudin-1
Claudin-2
Chloride
Diarrhea
Coptis
Blood
Zeitschrift für Gastroenterologie
