CareLit Fachartikel

Functional integration of parietal lobe activity in early Alzheimer’s disease

HIL Jacobs, MPJ van Boxtel, A Heinecke, EHBM Gronenschild, WH Backes, IHGB Ramakers, J Jolles, FRJ Verhey · Klinische Neurophysiologie · 2012 · Heft 03

Dokument
1140654
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
HIL Jacobs, MPJ van Boxtel, A Heinecke, EHBM Gronenschild, WH Backes, IHGB Ramakers, J Jolles, FRJ Verhey
Ausgabe
Heft 03 / 2012
Seiten
–
Erschienen: 2012-03-05 00:00:00
ISSN
1434-0275
DOI
10.1055/s-0032-1301598

Zusammenfassung

Objectives: Parietal lobe dysfunction is an important characteristic of early Alzheimer’s disease (AD). Functional studies have shown conflicting parietal activation patterns indicative of either compensatory or dysfunctional mechanisms. This study aimed at examining activation differences in early AD using a visuospatial task. We focused on functional characteristics of the parietal lobe and examined compensation or disconnection mechanisms by combining a fMRI task with effective connectivity measures from Granger Causality Mapping (GCM). Methods: Eighteen male patients with amnestic mild cognitive impairment (…

Schlagworte

Parietal Connectivity Patients Functional Early Activation Alzheimer Disease Mechanisms Differences Effective Results Klinische Neurophysiologie