Haematopoietic Stem Cell Survival and Transplantation Efficacy is Limited by the BH3-only Proteins Bim and Bmf
D Bertele, V Labi, C Woess, G Grothe, S Schwemmers, HL Pahl, S Geley, M Kunze, CM Niemeyer, A Villunger, M Erlacher · Klinische Pädiatrie · 2012 · Heft 04
Bibliografische Angaben
Zusammenfassung
Cell death occurring in haematopoietic stem cells (HSC) is critically involved in limiting successful stem cell transfer. It is known that HSC homeostasis is regulated by anti-apoptotic Bcl-2 family members, but little is known about the role of their antagonists, the “BH3-only” proteins. We determined the consequences of BH3-only protein depletion on HSC survival in vitro and in vivo. Thereby, we identified two BH3-only proteins, Bim and Bmf, as regulators of HSC survival. Bim-/- or bmf-/- HSC performed better during early engraftment and long term reconstitution of the haematopoietic system. In competitive tra…
