LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling
S Lindner, J Molenaar, T Thor, A Sprüssel, HN Caron, R Versteeg, A Schramm, A Eggert, JH Schulte · Klinische Pädiatrie · 2012 · Heft 04
Bibliografische Angaben
Zusammenfassung
LIN28b is overexpressed in many malignancies, including neuroblastoma (NB). LIN28b represses let-7 miRNAs which target MYC, RAS and MYCN. We here describe for the first time that LIN28b has the potential to initiate NBs. We established a genetically engineered mouse model overexpressing murine Lin28b in the neural crest and its derivates. The spontaneously arising tumors were analysed using IHC, western blot and RT-qPCR. Tumors originated from locations also common for human NB (e.g. adrenal). All tumors consisted of small round blue cells and expressed TH, DBH and Phox2b, confirming them to be NBs. While MYCN w…
