Epigenetic alterations in colorectal adenomas outnumber those in cancer. Is adenoma-dysplasia-carcinoma sequence a non-sequential process at the molecular level?
VÁ Patai, O Galamb, G Valcz, A Kalmár, Á Patai, B Péterfia, B Wichmann, K Leiszter, K Tóth, A Schöller, I Fűri, B Barták, Z Nagy, B Molnár, Z Tulassay · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: The adenoma-dysplasia-carcinoma sequence (ADCS) driven by sequential accumulation of genetic mutations is a widely accepted concept in colorectal carcinogenesis. In some proximal cancers arising from different precursor lesions DNA methylation has been shown to be an important mechanism, however in the distal colon DNA methylation has scarcely been studied. Aims: Our primary aim was to study DNA methylation alterations in 96 genes during ADCS, to identify characteristic methylation pattern for the distal colon and to compare the different stages. Our further aim was to correlate our DNA methylation p…
