Interplay of autophagy and apoptosis in steatohepatitis and hepatocellular carcinoma
V Mahajan, A Nikam, AK Mehta, K Kashofer, M Gauster, B Huppertz, H Denk, K Zatloukal, J Haybaeck · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and Aims: Chronic degenerative liver diseases such as alcoholic steatohepatitis (ASH), α-1 antitrypsin deficiency (α-1AT), and hepatocellular carcinoma (HCC) are characterized by presence of the inclusion bodies in hepatocytes namely Mallory-Denk bodies (MDBs) and Intracellular Hyaline Bodies (IHBs). We investigated the crossroads of apoptosis and autophagy as well as oxidative stress pathways in ASH, HCC and α-1AT deficiency. Methods: The expression levels of genes involved in macroautophagy and chaperon mediated autophagy (CME) were investigated by real time PCR in clinical specimens and also in mou…
