LMP7 Subunit Deficiency of the Immunoproteasome Leads to reduced Th2 Response in OVA/Alum Acute Asthma
A Volkov, S Hagner-Benes, S Löser, H Raifer, A Hellhund, S Alnahas, A Visekruna, H Garn, M Lohoff, H Renz, U Steinhoff · Pneumologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
LMP7 subunit of the immunoproteasome has been shown to play an important role in Th1/Th17 driven models of colitis and arthritis. However, nothing is known about LMP7 function in Th2 dependent diseases. To study the role of LMP7 in Th2 driven pathology, experimental allergic asthma was selected as a model of the medically relevant disease. We used WT and LMP7-/- knockout (KO) mice of C57BL/6N background for the induction of Alum/OVA, HDM and subcutaneous/OVA acute asthma. We found that LMP7 deficient mice showed reduced OVA/Alum acute asthma characterized by decreased bronchoalveolar lavage (BAL) eosinophilia, O…
