Iron induced HIF destabilization and altered Cellular Homeostatic Mechanisms in Cystic Fibrosis Cell Lines

Introduction: Cystic fibrosis (CF) is commonly associated with bacterial infection of the airways usually with P. aeruginosa and S. aureus. The chronic endobronchial inflammation due to persistent bacterial infection leads to progressive lung disease and is the main cause of mortality and morbidity in CF. Toll like receptors (TLR) act as sensors for the bacterial infections through conserved pathogen assisted molecular patterns (PAMPS), which mediate inflammation and innate immune responses of the lung via TLR signaling. LPS induced TLR4 signaling not only recruits inflammatory cytokines but also induces anti-in…