Regulation of Macroautophagy in Idiopathic Pulmonary Fibrosis

Introduction: It is currently unknown if lysosome related pathways are altered under conditions of idiopathic pulmonary fibrosis (IPF). Autophagy has been known from several years as a self-eating catabolic pathway, activated mainly to degrade the cell's own unused organelles, macromolecules and long-lived proteins via the lysosomal system. Macroautophagy is a well characterized and one of the important types of autophagy that contributes to lysosomal degradation. It involves sequestration of a double membrane structure called autophagosome, which will finally fuse with the lysosome for degradation of its conten…