Circulating microRNAs associated with early relapse in early-stage NSCLC
S Kaduthanam, S Gade, T Muley, M Meister, JC Brase, M Johannes, F Herth, H Dienemann, H Sültmann, R Kuner · Pneumologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: In early-stage tumors the outcome is critically determined by metastatic spread: About 30–50% of patients encounter a recurrence after surgery of lung cancer. The stratification of early-stage lung cancer with high risk for recurrence will improve therapy management and patient care. The aim of the study was to identify microRNAs in serum associated with early relapse in non-small cell lung cancer. Material and methods: Serum samples and RNA extracts were collected from 232 patients including NSCLC disease and control samples. We performed qRT-PCR based microRNA screening from a subset of 40 patients…
