Expression and function of the immunomodulatory receptor OSCAR in the vascular system

Introduction: The osteoclast-associated receptor (OSCAR) is a member of the leukocyte receptor complex (LRC)-encoded family of surface receptors. So far, OSCAR was identified and characterized on immune cells and osteoclasts. We confirmed the expression of OSCAR on endothelial cells (EC) and vascular smooth muscle cells (VSMC). The aim of this study was to characterize the regulation and possible function of OSCAR by endothelial growth factors and inflammatory mediators in EC and VSMC. Material: OSCAR was detected on human EC and VSMC by immunofluorescence and Western blot. OSCAR-expression of the membrane, cyto…