CareLit Fachartikel
Differential expression of Neuropeptide Y (NPY) and NPY receptors 1/2 between rat lung and kidney allografts
J Schmitz, A Zakrzewicz, S Wilker, J Kuncová, W Padberg, V Grau, J Holler · Pneumologie · 2012 · Heft 05
Dokument
1141161
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Jahr
2012
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Zusammenfassung
Recently, our group described a strong leukocytic expression of NPY in the rat. During acute renal graft rejection, we observed a drastical down-regulation of NPY by mononuclear leukocytes accumulating in blood vessels of rat kidneys. Concurrently, the expression of NPY receptors Y1 and Y2 was increased. NPY, a sympathetic co-mediator modulating immune functions, may regulate leukocyte accumulation in graft blood vessels. Lung transplantation is the therapeutic measure of last resort for patients with end-stage lung disease. Compared to kidney transplants, the long-term outcomes of lung grafts are worse. This st…
Schlagworte
Allografts
Blood Vessels
Blood
After
Transplantation
Pneumologie
