The Pediatric Brain Tumor Preclinical Testing Program: an update on the current status

The Pediatric Brain Tumor Preclinical Testing Program aims at the evaluation of the clinical benefit and of the feasibility of an individualized treatment approach. To this aim, we are including all available pediatric brain tumors independent of the histological diagnosis from ten pediatric oncology centers. All tumors are subjected to molecular analyis by array-comparative genomic hybridization (aCGH) and gene expression profiling, allowing for identification of activated signaling pathways. Primary tumor material is transplanted orthotopically into mice. Secondary xenografts will be treated according to the r…