CareLit Fachartikel
Loss of ATM increases cancer formation in a mouse model of human pancreatic ductal adenocarcinoma
A Kleger, R Russell, L Perkhofer, KL Rudolph, M Wagner · Zeitschrift für Gastroenterologie · 2012 · Heft 08
Dokument
1141489
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Jahr
2012
Publikation
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Zusammenfassung
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths in the developed world, with a 5 year survival rate as low as 5%. In recent years, genetically engineered animal models of pancreatic cancer which recapitulate the human disease have provided a useful means of studying both the morphological and molecular features associated with PDAC. The most commonly studied model to date has been the expression of active Kras under the control of an endogenous, pancreas specific promoter which leads to a spectrum of changes in the pancreas recapitulating development of human PDAC. Interesti…
Schlagworte
Adenocarcinoma
Address
Ataxia
Axis
ATM Protein
ATM-Protein
Actin
Tumor
Zeitschrift für Gastroenterologie
