CareLit Fachartikel
IL-27 activates MHC class II expression in intestinal epithelial cells via STAT1-dependent class II transactivator (CIITA) induction
J Diegelmann, M Friedrich, S Brand · Zeitschrift für Gastroenterologie · 2012 · Heft 08
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1141493
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Jahr
2012
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Zusammenfassung
Introduction: IL-27 is a Th17-cell inhibiting cytokine produced by antigen presenting cells. We recently demonstrated anti-inflammatory and antibacterial functions for IL-27 in intestinal epithelial cells (IEC) and identified CIITA as IL-27 target gene [1]. Both IL-27 and CIITA have been implicated in the susceptibility to inflammatory bowel diseases and certain autoimmune diseases. Here we aimed to analyze the role of IL-27-induced CIITA expression in IEC. Methods: IL-27-induced gene expression and activated signaling pathways were analyzed by microarray, quantitative PCR and western blot experiments. Gene expr…
Schlagworte
After
Antigen-Presenting Cells
Antigen Presentation
Autoimmune Diseases
Cytokine
Zeitschrift für Gastroenterologie
