Platelet-protein-profiling of healthy controls and patients with early- and late-stage colorectal cancers

Aims: Early tumor detection and intervention are important determinants of survival in patients with cancer. During early tumor growth, platelets actively and selectively sequester proteins and, as such, the platelet protein content can be used as a marker of early tumor growth. We therefore aimed at identifying differenzially expressed proteins of platelets that distinguish healthy controls from patients with early- and late-stage colorectal cancer. Such markers might serve for innovative early detection, prognosis and therapeutic intervention. Material and methods: We compared multiplex-fluorescence two-dimens…